Glycosyltransferase vectors for treating cancer
AssigneeGeron Corporation
InventorJ. Michael Schiff
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Abstract
This disclosure provides a system for specifically killing cancer cells which can be used in the course of human therapy. Vectors of the invention comprise an encoding sequence for a glycosyltransferase, under control of a tumor or tissue specific transcriptional control element, such as the promoter for telomerase reverse transcriptase. Exemplary glycosyltransferases are the A or B transferase enzymes, which cause the cancer cells to express ABO histo blood group allotypes against which humans have naturally occurring antibody. This provides for ongoing surveillance for newly emerging cells with a malignant phenotype.
Claims10
An isolated polynucleotide encoding SEQ. ID NOs:12, SEQ. ID NO:13, or a fragment of SEQ. ID NO:13, wherein said fragment has glycosyltransferase activity, under control of a telomerase transcriptional control element.
An isolated polynucleotide comprising an encoding sequence for a humanized or consensus α(1,3)galactosyltransferase, comprising the amino acid sequence shown in SEQ. ID NO:12, SEQ. ID NO:13, or a fragment of SEQ. ID NO:13, wherein said fragment has glycosyltransferase activity.
Dependencies are inferred from the claim text.