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US 6,713,050 B2Granted
Method and composition for rejuvenating hairs, nails, tissues, cells and organs by ex-vivo or immersive treatment
AssigneeFarrington Pharmaceuticals, LLC
InventorsMichael A. Brines, Anthony Cerami
Life of this patent
Estimating the term…
Abstract
A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula (I): or the formula (II):
Claims24
A composition for the treatment of nails to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula (I):
- wherein R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy(lower alkyl), lower acyloxy(lower alkyl), lower alkyl, lower alkenyl, or R1 and R2 together with their ring carbons may be an aromatic fused ring, optionally substituted by one or more amino, halo or alkylenedioxy groups;
- Z is hydrogen or an amino group;
- Y is amino,
- or a group of the formula —CH2C(═O)—R wherein R is a lower alkyl, alkoxy, hydroxy, amino or aryl group;
- said aryl group optionally substituted by one or more lower alkyl, lower alkoxy, halo, dialkylamino, hydroxy, intro or alkylenedioxy groups,
- or a group of the formula —CH2R′ wherein R′ is hydrogen, or a lower alkyl, lower alkynyl, or aryl group,
- or a group of the formula —CH2C(═O)—N(R″)R′″ wherein (a) R″ is hydrogen and R′″ is a lower alkyl group optionally substituted by a C6-C10 aryl group, or a C6-C10 aryl group, said aryl groups optionally substituted by one or more lower alkyl, halo, or (lower alkoxy)carbonyl groups;
- or (b) R″ and R′″ are both lower alkyl groups;
- and
- X is a halide, tosylate, methanesulfonate, mesitylenesulfonate, or other pharmacologically acceptable anion and mixtures thereof, and a carrier therefore;
- wherein the effective amount is sufficient to treat at least one of the following:
- (a) damaged nails;
- (b) physiologically aged nails;
- and (c) diseased nails (e.g. diabetes);
- and wherein the composition is in the form of a nail polish.
12 more elements
A composition for the treatment of nails to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula (II):
- wherein R1 and R2 are independently selected from the group consisting of hydrogen and an alkyl group optionally substituted by a hydroxy group;
- Y is a group of the formula —CH2C(═O)R wherein R is a heterocyclic group containing 4-10 ring members and 1-3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur;
- said heterocyclic group optionally substituted by one or more substituents selected from the group consisting of alkyl, oxo, alkoxycarbonylalkyl, aryl, aralkyl groups;
- and said one or more substituents optionally substituted by one or more alkyl or alkoxy groups;
- or a group of the formula —CH2C(═O)—NHR′ wherein R′ is a heterocyclic group containing 4-10 ring members and 1-3 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur;
- said heterocyclic group optionally substituted by one or more alkoxycarbonylalkyl groups;
- and X is a halide, tosylate, methanesulfonate, or mesitylenesulfonate ion, or other pharmacologically acceptable anion;
- wherein the effective amount is sufficient to treat at least one of the following:
- (a) damaged nails;
- (b) physiologically aged nails;
- and (c) diseased nails (e.g.diabetes);
- and wherein the composition is in the form of a nail polish.
9 more elements
A method for the treatment of at least one of the following:
- (a) damaged nails;
- (b) physiologically aged nails;
- and (c) diseased nails (e.g. diabetes) to improve the biomechanical and functional properties comprising externally contacting the nail with an effective amount of composition in the form of a nail polish comprising a compound selected from the group consisting of compounds of the formula (I):
- wherein R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy(lower alkyl), lower acyloxy(lower alkyl), lower alkyl, lower alkenyl, or R1 and R2 together with their ring carbons may be an aromatic fused ring, optionally substituted by one or more amino, halo or alkylenedioxy groups;
- Z is hydrogen or an amino group;
- Y is amino,
- or a group of the formula —CH2C(═O)—R wherein R is a lower alkyl, alkoxy, hydroxy, amino or aryl group;
- said aryl group optionally substituted by one or more lower alkyl, lower alkoxy, halo, dialkylamino, hydroxy, nitro or alkylenedioxy groups,
- or a group of the formula —CH2R′ wherein R′ is hydrogen, or a lower alkyl, lower alkynyl, or aryl group,
- or a group of the formula —CH2C(═O)—N(R′)R′″ wherein (a) R′ is hydrogen and R′″ is a lower alkyl group optionally substituted by a C6-C10 aryl group, or a C6-C10 aryl group, said aryl groups optionally substituted by one or more lower alkyl, halo, or (lower alkoxy)carbonyl groups;
- or (b) R″ and R′″ are both lower alkyl groups;
- and
- X is a halide, tosylate, methanesulfonate, mesitylenesulfonate, or other pharmacologically acceptable anion and mixtures thereof, and a carrier therefor.
10 more elements
A method for the ex-vivo treatment of at least one of the following:
- (a) damaged nails;
- (b) physiologically aged nails;
- and (c) diseased nails (e.g. diabetes) to improve the biomechanical and functional properties comprising externally contacting the nail with an effective amount of a composition in the form of a nail polish comprising a compound selected from the group consisting of compounds of the formula (II):
- wherein R1 and R2 are independently selected from the group consisting of hydrogen and an alkyl group optionally substituted by a hydroxy group;
- Y is a group of the formula —CH2C(═O)R wherein R is a heterocyclic group containing 4-10 ring members and 1-3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur;
- said heterocyclic group optionally substituted by one or more substituents selected from the group consisting of alkyl, oxo, alkoxycarbonylalkyl, aryl, aralkyl groups;
- and said one or more substituents optionally substituted by one or more alkyl or alkoxy groups;
- or a group of the formula —CH2C(═O)—NHR′ wherein R′ is a heterocyclic group containing 4-10 ring members and 1-3 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur;
- said heterocyclic group optionally substituted by one or more alkoxycarbonylalkyl groups;
- and X is a halide, tosylate, methanesulfonate, or mesitylenesulfonate ion, or other pharmacologically acceptable anion.
7 more elements
A method for the ex vivo treatment of organs, cells or tissues removed from an animal to improve the biomechanical and functional properties comprising externally contacting the removed organ, removed cell or removed tissue with an effective amount of composition comprising a compound selected from the group consisting of compounds of the formula (I):
- wherein R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy(lower alkyl), lower acyloxy(lower alkyl), lower alkyl, lower alkenyl, or R1 and R2 together with their ring carbons may be an aromatic fused ring, optionally substituted by one or more amino, halo or alkylenedioxy groups;
- Z is hydrogen or an amino group;
- Y is amino,
- or a group of the formula —CH2C(═O)—R wherein R is a lower alkyl, alkoxy, hydroxy, amino or aryl group;
- said aryl group optionally substituted by one or more lower alkyl, lower alkoxy, halo, dialkylamino, hydroxy, nitro or alkylenedioxy groups,
- or a group of the formula —CH2R′ wherein R′ is hydrogen, or a lower alkyl, lower alkynyl, or aryl group,
- or a group of the formula —CH2C(═O)—N(R″)R′″ wherein (a) R″ is hydrogen and R′″ is a lower alkyl group optionally substituted by a C6-C10 aryl group, or a C6-C10 aryl group, said aryl groups optionally substituted by one or more lower alkyl, halo, or (lower alkoxy)carbonyl groups;
- or (b) R″ and R′″ are both lower alkyl groups;
- and
- X is a halide, tosylate, methanesulfonate, mesitylenesulfonate, or other pharmacologically acceptable anion and mixtures thereof, and a carrier therefore.
7 more elements
A method for the ex-vivo treatment of organs, cells or tissues removed from an animal to improve the biomechanical and functional properties comprising externally contacting the removed organ, removed cell or removed tissue with an effective amount of composition comprising a compound selected from the group consisting of compounds of the formula (II):
- wherein R1 and R2 are independently selected from the group consisting of hydrogen and an alkyl group optionally substituted by a hydroxy group;
- Y is a group of the formula —CH2C(═O)R wherein R is a heterocyclic group containing 4-10 ring members and 1-3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur;
- said heterocyclic group optionally substituted by one or more substituents selected from the group consisting of alkyl, oxo, alkoxycarbonylalkyl, aryl, aralkyl groups;
- and said one or more substituents optionally substituted by one or more alkyl or alkoxy groups;
- or a group of the formula —CH2C(═O)—NHR′ wherein R′ is a heterocyclic group containing 4-10 ring members and 1-3 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur;
- said heterocyclic group optionally substituted by one or more alkoxycarbonylalkyl groups;
- and X is a halide, tosylate, methanesulfonate, or mesitylenesulfonate ion, or other pharmacologically acceptable anion.
4 more elements
Dependencies are inferred from the claim text.