Pharmaceutical aerosol composition containing HFA 227 and HFA 134a
AssigneeChiesi Farmaceutici S.p.A.
InventorsDavid Lewis, David Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
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Abstract
In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler to target specific regions of the respiratory tract. Moreover the fine particle dose (FPD) of the active ingredient in the composition increases by reducing the metering chamber volume.
Claims29
A composition in the form of a solution comprising:
- a solubilized active material,
- a propellant comprising HFA 227 and HFA 134a, and
- optionally, a low volatility component, or a cosolvent, or both,
- wherein the ratio of HFA 227:
- HFA 134a ranges from 10:90 to 90:10 and
- the active material is an anticholinergic drug, a corticosteroid, or a β2 agonist.
An aerosol inhaler comprising a composition in the form of a solution wherein said solution comprises an active material, a propellant containing one or more hydrofluoroalkane(s), a cosolvent and optionally a low volatility component,
- wherein the particle MMAD produced by said aerosol inhaler is greater than 2 μm and the fine particle dose (<4.7 μm) is >30%,
- with the proviso that the active material is not Cyclosporin A.
A delivery system for the administration of one or more drugs to the lung consisting of aerosol drug solution in a mixture of 134a and 227 HFA propellants, a cosolvent and optionally a low volatility component, in an aerosol inhaler having a chamber volume ranging from 25 to 40 μm, wherein the MMAD of the aerosol particles on actuation of the inhaler is not less than 2 μm and the fine particle dose (<4.7 μm) is at least 30%.
Dependencies are inferred from the claim text.