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US 6,713,046 B1Granted
Magnetic resonance imaging agents for the delivery of therapeutic agents
AssigneeResearch Corporation Technologies, Inc.
InventorThomas J. Meade
Life of this patent
Estimating the term…
Abstract
The invention relates to novel magnetic resonance imaging contrast agents and methods of delivering therapeutically active agents.
Claims16
A method comprising:
- a) administering an MRI agent having the formula comprising:
- b) exposing said MRI agent to light to cleave said photocleavable moiety such that the exchange of water in at least one coordination site of said MRI agent is increased;
- and,
- c) producing a magnetic resonance image of a cell, tissue, or patient and eliciting a therapeutic effect.
1 more element
A method comprising:
- a) administering an MRI agent having the formula comprising:
- wherein said linker is an aryl or alkyl group;
- b) exposing said MRI agent to light to cleave said photocleavable moiety such that the exchange of water in at least one coordination site of said MRI agent is increased;
- and,
- c) producing a magnetic resonance image of a cell, tissue, or patient and eliciting a therapeutic effect.
2 more elements
A method comprising:
- a) administering an MRI agent having the formula comprising:
- b) exposing said MRI agent to light to cleave said photocleavable moiety such that the exchange of water in at least one coordination site of said MRI agent is increased;
- and,
- c) producing a magnetic resonance image of a cell, tissue, or patient and eliciting a therapeutic effect.
1 more element
A method comprising:
- a) administering an MRI agent having the formula comprising:
- b) exposing said MRI agent to light to cleave said photocleavable moiety, wherein upon cleavage of said photocleavable moiety the T1 of the agent is decreased, and,
- c) producing a magnetic resonance image of a cell, tissue, or patient and eliciting a therapeutic effect.
A method comprising:
- a) administering an MRI agent having the formula comprising:
- wherein said linker is an aryl or alkyl group selected from the group consisting of substituted alkyl, heteroalkyl, substituted heteroalkyl, substituted aryl, heteroaryl and substituted heteroaryl;
- b) exposing said MRI agent to light to cleave said photocleavable moiety wherein upon cleavage of said photocleavable moiety the T1 of the agent is decreased;
- and,
- c) producing a magnetic resonance image of a cell, tissue, or patient and eliciting a therapeutic effect.
2 more elements
A method comprising:
- a) administering an MRI agent having the formula comprising:
- b) exposing said MRI agent to light to cleave said photocleavable moiety wherein upon cleavage of said photocleavable moiety the T1 of the agent is decreased;
- and,
- c) producing a magnetic resonance image of a cell, tissue, or patient and eliciting a therapeutic effect.
1 more element
Dependencies are inferred from the claim text.