Antimicrobial activity of gemfibrozil

A method of selecting a compound which inhibits the enzymatic activity of enoyl reductase which comprises:

• (A) contacting enoyl reductase with the compound;
• (B) measuring the enzymatic activity of the enoyl reductase of step (A) compared with the enzymatic activity of enoyl reductase in the absence of the compound, and selecting the compound which inhibits the enzymatic activity of enoyl reductase
• wherein the compound has the structure:
• wherein each of R1, R2, R3, R4, R5 and R6 is independently selected from the group consisting of H, F, Cl, Br, I, _OH, —OR7, —ON, —COR7, —SR7—, —N(R7)2, —NR7COR8, —NO2, a straight chain or branched, substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, and heteroaryl;
• wherein each of R7 and R8 is independently selected from the group consisting of H, F, Cl, Br, I, —OH, —CN, —COH, —SH2, —NH2, —NHCOH, —(CH2)pOH, a straight chain or branched, substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, thioalkyl, methylene thioalkyl, acyl, phenyl, substituted phenyl, and heteroaryl;
• wherein A is selected from the group consisting of —N2—, —NH—, —CH═C=CH—, —C≡C—CHOH—, —C≡C—CH2—, —CH2—CH2—O—, —CH2—CH2—CH2—O—, —S—, —S(═O)2, —C(═O)—, —C (═O)—O—, —NH—C(═O)—, and —C (═O)—NH—;
• and
• wherein each of Q and p is independently an integer from 1 to 10, and if Q is 1, A is selected from the group consisting of a (C1-C10)-alkyl chain, a (C2-C10)-alkenyl chain, a (C2-C10)-alkylene chain or a (C2-C10)-alkynyl chain which is branched or unbranched, substituted or unsubstituted and is optionally interrupted 1 to 3 times by —O— or —S— or —N—.