Process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin, an adsorbent and method of producing an adsorber from the adsorbent
AssigneeFresenius HemoCare GmbH
InventorsHans-Peter Leinenbach, Heike Mitschulat, Wolfgang Metzger, Veit Otto, Martin Hepper
Life of this patent
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Abstract
A process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma in which a carrier material, which is preferably a copolymer derived from (meth)acrylates and or (meth)acrylic acid amides, is activated by amination, and subsequently undergoes thermal treatment at a temperature of over 100° C. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.
Claims10
An adsorbent for reducing the concentration of at least one of fibrinogen and fibrin in blood or blood plasma, comprising:
- a carrier material comprising a statistical copolymer produced by the suspension polymerization of the monomeric unit of (meth)acrylic amide in a quantity of 10 to 30% by weight, the monomeric unit of N,N′-methylene-bis(meth)acrylamide in a quantity of 30 to 80% by weight, and at least one of the monomeric units of allyl glycidyl ether and glycidyl-(meth)acrylate in a quantity of 10 to 20% by weight, wherein the percentages by weight are relative to the total weight of all of the monomeric units;
- and
- at least one amine group covalently bonded to the carrier material via the utilization of an aqueous solution of ammonia;
- wherein the adsorbent has been thermally treated at a temperature of over 100° C.
A method of producing an adsorber for the purpose of reducing the concentration of at least one of fibrinogen and fibrin in blood or blood plasma, said method comprising:
- adding an adsorbent to a housing to form an adsorber, wherein the adsorbent comprises:
- a carrier material comprising a statistical copolymer produced by the suspension polymerization of the monomeric unit of (meth)acrylic amide in a quantity of 10 to 30% by weight, the monomeric unit of N,N′-methylene-bis(meth)acrylamide in a quantity of 30 to 80% by weight, and at least one of the monomeric units of allyl glycidyl ether and glycidyl-(meth)acrylate in a quantity of 10 to 20% by weight, wherein the percentages by weight are relative to the total weight of all of the monomeric units;
- and at least one amine group covalently bonded to the carrier material via the utilization of an aqueous solution of ammonia;
- wherein the adsorbent has been thermally treated at a temperature of over 100° C.
An adsorber for the purpose of reducing the concentration of at least one of fibrinogen and fibrin in blood or blood plasma, comprising:
- a housing;
- and
- an adsorbent contained by the housing, wherein the adsorbent comprises:
- a carrier material comprising a statistical copolymer produced by the suspension polymerization of the monomeric unit of (meth)acrylic amide in a quantity of 10 to 30% by weight, the monomeric unit of N,N′-methylene-bis(meth)acrylamide in a quantity of 30 to 80% by weight, and at least one of the monomeric units of allyl glycidyl ether and glycidyl-(meth)acrylate in a quantity of 10 to 20% by weight, wherein the percentages by weight are relative to the total weight of all the monomeric units;
- and at least one amine group covalently bonded to the carrier material via the utilization of an aqueous solution of ammonia;
- wherein the adsorbent has been thermally treated at a temperature of over 100° C.
Dependencies are inferred from the claim text.