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AssigneesInstitut Francais du Petrole, Novasep
InventorsPhillippe Adam, Roger Marc Nicoud, Michel Bailly, Olivier Ludemann-Hombourger
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A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable. The process is useful for the separation particularly of stereoisomers for pharmaceuticals.
A non-simulated-moving-bed (non-SMB) process for separating at least one component of a mixture that contains it, comprising introducing said mixture into a non-SMB device that has a set of chromatographic columns or chromatographic column sections that contain an adsorbent and are arranged in series and in a loop, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a chromatographic zone is determined between an injection point and a draw-off point or vice-versa, and wherein at the end of a given period of time all of the injection and draw-off points are shifted by the same number of columns or column sections, and during said period, shifting different injection and draw-off points at different times such that the lengths of the zones that are defined by said different points are variable.
A non-simulated-moving-bed (non-SMB) process for separating at least one component of a mixture that contains it, comprising introducing said mixture into a non-SMB device that has a set of chromatographic columns or chromatographic column sections that contain an adsorbent and are arranged in series and in a loop, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a chromatographic zone is determined between an injection point and a draw-off point or vice-versa, and wherein at the end of a given period of time all of the injection and draw-off points are shifted by the same number of columns or column sections, and during said period, shifting different injection and draw-off points at different times such that the lengths of the zones that are defined by said different points are variable.
Dependencies are inferred from the claim text.