Polymer-coated stents, processes for producing the same and their use for restenosis prevention

A process for preparing a polymer-coated stent, comprising coating a metallic base stent by chemical vapor deposition with a polymer that has functional groups, and covalently bonding a hydrophilic chelating or inclusion agent by chemical reaction to the functional groups.

A process for preparing a polymer-coated stent, comprising coating a metallic base by chemical vapor deposition with a polymer that has functional groups, then treating the coated metallic base stent with a solution that contains spacer molecules whereby the spacer molecules covalently bond to the functional groups, and then further treating the coated metallic base stent with a solution that contains a hydrophilic chelating or inclusion agent that covalently bonds to the spacer molecules and/or the functional groups that do not contain a spacer molecule.

A process for preparing a polymer-coated stent, comprising coating a base stent with a polymer having functional groups by plasma polymerization, and covalently bonding a hydrophilic chelating or inclusion agent by chemical reaction to the functional groups.

A process for preparing a polymer-coated stent, comprising coating abase stent with a polymer having functional groups by plasma polymerization, then treating the coated base stent with a solution that contains spacer molecules whereby the spacer molecules covalently bond to the functional groups, and then further treating the base stent with a solution that contains a hydrophilic chelating or inclusion agent that covalently bonds to the spacer molecules and/or the functional groups that do not contain a spacer molecule.

A process for preparing a polymer-coated stent, comprising coating a metallic base stent with a polymer having functional groups by chemical vapor deposition, and covalently bonding a cyclodextrin derivative by chemical reaction to the functional groups.

A process for preparing a polymer-coated stent, comprising coating a metallic base stent with a polymer having functional groups by chemical vapor deposition, then treating the coated metallic base stent with a solution containing spacer molecules whereby the spacer molecules covalently bond to the functional groups, and then further treating the base stent with a solution containing a cyclodextrin derivative that covalently bonds to the spacer molecules and/or the functional groups that do not contain a spacer molecule.

A polymer-coated stent, comprising a base stent on which a polymer is applied that has a hydrophilic chelating or inclusion agent covalently bonded to the surface thereof, and has one or more radioisotopes and/or one or more therapeutic agents either complexed with the hydrophilic chelating or inclusion agent or forms an inclusion compound with the hydrophilic chelating or inclusion agent on the surface of the stent, wherein the polymer layer is an outermost or exterior polymer layer on the surface of the stent.