Ω-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists

A method of treating ocular hypertension which comprises administering to a mammal having ocular hypertension a therapeutically effective amount of a compound represented

• formula II:
• wherein the hatched segment represents an α bond, the solid triangle represents a β bond, the wavy segment represents α or β bond, dashed lines represent a double bond or a single bond, X is selected from the group consisting of hydrogen and halogen radicals, R1 and R2 are independently selected from the group consisting of hydrogen or a lower alkyl radical having up to six carbon atoms, or a lower acyl radical having up to six carbon atoms, R is selected from the group consisting of CO2R4, CONR42, CH2OR4, CONR4SO2R4, P(O)(OR4) and
• wherein R4 is selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms Z is selected from the group consisting of O and S, A is selected from the group consisting of N, —CH, and C, R5 is selected from the group consisting of hydrogen, halogen, lower alkyl having from 1 to 6 carbon atoms, and lower alkoxy having from 1 to 6 carbon atoms, R6 and R7 are selected from the group consisting of hydrogen, halogen, lower alkyl having from 1 to 6 carbon atoms, lower alkoxy having from 1 to 6 carbon atoms or, together with
• R6 and R7 forms a condensed aryl ring and n is 0 or an integer of from 1 to 4.