Multivesicular emulsion drug delivery systems
AssigneeHealthpoint, Ltd.
InventorRobert Espinoza
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Abstract
A topical delivery composition which employs a multivesicular emulsion in combination with a pharmaceutically/pharmacologically active agent is disclosed. The multivesicular emulsion is formed from a quaternary amine salt emulsifier such as behentrimonium methosulfate. The emulsion is multi-lamellar which is a series of concentric spheres or vesiculars of oil and water phase that can be seen microscopically. As a result, the active is time released over a sustained period rather than spike released as is common with most topicals.
Claims16
A topical delivery composition which comprises a multivesicular emulsion consisting essentially of from 0.1% to 30% by weight of total composition of a quaternary amine salt emulsifier system and a pharmaceutically/pharmacologically active agent entrapped within the vesicles, wherein said emulsifier system is a behentrimonium methosulfate system, and wherein said multivesicular emulsion is a two-phase, oil-in-water emulsion system which has a multilamellar series of concentric spheres or shells of oil and water phases.
A method of preparing a topical delivery composition which comprises a multivesicular emulsion consisting essentially of a quaternary amine salt emulsifier system and a pharmaceutically/pharmacologically active agent entrapped within the vesicles, wherein said emulsifier system is a behentrimonium methosulfate system, and wherein said multivesicular emulsion is a two-phase, oil-in-water emulsion system which has a multilamellar series of concentric spheres or shells of oil and water phases, said method comprising:
- mixing the pharmaceutically/pharmacologically active agent with a compatible base which is either an oil phase or a water phase, depending upon the active and thereafter;
- mixing the active agent and base with from 0.1% to 30% by weight of the total composition of the quaternary amine salt emulsifier system until a multivesicular emulsion capable of timed active release is provided.
Dependencies are inferred from the claim text.