Hemoactive compositions and methods for their manufacture and use
AssigneeBaxter Healthcare S.A.
InventorsCary J. Reich, A. Edward Osawa, Helen Tran
Life of this patent
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Abstract
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery.
Claims27
A dried material which forms a hydrogel when exposed to blood, said material comprising:
- a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood;
- a non-cross-linked biologically compatible polymer which dissolves when exposed to blood;
- a plasticizer present in the non-cross-linked biologically compatible polymer;
- and
- wherein the cross-linked polymer is dispersed in a dried matrix of the non-cross-linked polymer, wherein the non-cross-linked biologically compatible polymer dissolves in 15 minutes or less when exposed to blood.
A dried material which forms a hydrogel when exposed to blood comprising:
- a non-cross-linked biologically compatible polymer comprising a non-cross-linked dry gelatin matrix which dissolves when exposed to blood;
- a cross-linked biologically compatible polymer comprising dry, cross-linked gelatin polymer particles dispersed in the dry non-cross-linked gelatin matrix, which particles form a hydrogel when the material is exposed to blood at 37° C. to dissolve the matrix;
- and
- a plasticizer present in the non-cross-linked biologically compatible polymer, wherein the non-cross-linked biologically compatible polymer dissolves in 15 minutes or less when exposed to blood.
A method for making a material, which forms hydrogel when exposed to blood said method comprising:
- dissolving a non-cross-linked biologically compatible polymer which dissolves when exposed to blood in an aqueous medium having a plasticizer;
- suspending particles of a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood in the aqueous medium;
- and
- drying the aqueous medium to form a solid phase comprising dried polymeric particles of the cross-linked biologically compatible polymer in a dry matrix of the non-cross-linked biologically compatible polymer.
Dependencies are inferred from the claim text.