Prebiotic and probiotic compositions and methods for their use in gut-based therapies
AssigneeKibow Biotech, Inc.
InventorsNataragan Ranganathan, Jack Dickstein, Raj Mehta
Life of this patent
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Abstract
Microencapsulated and/or enteric coated compositions containing a mixture of probiotics, prebiotics and ammoniaphilic bacteria with high urease activity with or without sorbents with specific adsorption affinities for uremic toxins such as creatinine, uric acid, phenols, indoles, middle molecular weight molecules and inorganic phosphate and water absorbents are provided. Also provided are methods of alleviating symptoms of uremia in a patient which comprises administering orally to a patient suffering from uremia a microencapsulated and/or enteric-coated composition.
Claims3
A pharmaceutical composition to alleviate the symptoms of uremia comprising a composition of a probiotic, a prebiotic, a sorbent for inorganic phosphate, an adsorbent for specific uremic solutes other then urea and ammoniaphilic urea degrading microorganism with high alkaline pH stability and high urease activity, said composition being microencapsulated or enteric coated with a material designed to deliver the probiotic, the prebiotic, and ammoniaphilic urea degrading microorganism to their site of action without binding of digestive materials to the composition prior to reaching the target region, wherein said prebiotic ensures the viability of the probiotic, and wherein said microencapsulated or enteric coating prevents the release of the ammoniaphilic urea degrading microorganism into the patient.
A pharmaceutical composition to alleviate the symptoms of uremia comprising a composition of a probiotic, a prebiotic, an ammoniaphilic urea degrading microorganism with high alkaline pH stability and high urease activity, a water absorbent, a sorbent for inorganic phosphate and an adsorbent for specific uremic solutes other than urea, said composition being microencapsulated or enteric coated with a material designed to deliver the probiotic, the prebiotic, and ammoniaphilic urea degrading microorganism to their site of action without binding of digestive materials to the composition prior to reaching the target region, and wherein said microencapsulated or enteric coating prevents the infection of a patient from the ammoniaphilic urea degrading microorganism.
Dependencies are inferred from the claim text.