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US 6,703,372 B1Granted
Macrolides
AssigneeBiochemie
InventorsVictor Centellas, Rafael Garcia, Marta Poch, José Diago, Johannes Ludescher, Immaculada Bosch
Life of this patent
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Abstract
Azithromycin in the form of a stable monohydrate and processes for the preparation of azithromycin in the form of an, e.g. stable, monohydrate.
Claims11
A process for the production of a compound of formula III
- comprising the steps
- i) treating a compound of formula II
- with a boronated hydride;
- ii) hydrolyzing an intermediate borate compound formed in the presence of a polyhydroxylated compound;
- and, if desired,
- iii) isolating a compound of formula III from the reaction mixture.
3 more elements
A process for the production of azithromycin in the form of a monohydrate comprising the steps of
- i) adjusting the pH of a solution of azithromycin in the form of a salt, wherein the solvent is only water;
- and
- ii) isolating azithromycin in the form of a monohydrate.
Azithromycin in the form of a monohydrate having an analytically detectable amount up to 0.5% w/w of organic solvent.
A pharmaceutical composition comprising
- monohydrate;
- a composition of azithromycin in the form of a monohydrate and an analytically detectable amount up to 0.5% w/w of organic solvent;
- in association with at least one pharmaceutical carrier or diluent.
Dependencies are inferred from the claim text.