Polymer blends as biodegradable matrices for preparing biocomposites
AssigneeIntralytix, Inc.
InventorsRamaz Katsarava, Zemphira Alavidze
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Abstract
The present invention provides bioerodable constructs for controlled release of bioactive materials. In a preferred mode, the constructs may be utilized adjacent to a biological surface. The constructs are based on a blend of two or more poly(ester-amide) polymers (PEA). Such polymers may be prepared by polymerization of a diol (D), a dicarboxylic acid (C) and an alpha-amino acid (A) through ester and amide links in the form (DACA)n. An example of a (DACA)n polymer is shown below in formula II. Suitable amino acids include any natural or synthetic alpha-amino acid, preferably neutral amino acids.
Claims21
A bioerodable construct for controlled release of bioactive materials, said construct comprising a blend of two poly(ester-amide) polymers (PEA) prepared by polymerizing a diol (D), a dicarboxylic acid (C) and an alpha-amino acid (A) through ester and amide links in the form (DACA)n.
- wherein the PEA polymer has the formula:
- wherein
- k=2-12,
- m=2-12,
- R=CH2CH(CH3)2 or CH2C6H5.
- and,
- wherein the ratio of Phe-PEA to Leu-PEA is from 10:1 to 1:1.
Dependencies are inferred from the claim text.