Prosthetic heart valve with surface modification
OwnerJoseph A. Chinn, Jack R. Frautschi +1inventors
InventorsJoseph A. Chinn, Jack R. Frautschi, Richard E. Phillips
Life of this patent
Estimating the term…
Abstract
A biocompatible heart valve is described having incorporated therein an effective amount of applied coating to render the valve resistant to in vivo pathologic thrombus formation and resistant to in vivo pathologic calcification.
Claims4
A method for reducing calcification and thrombus formation in a biocompatible heart valve comprising a polymer selected from the group consisting of silicone rubbers, polyurethane, and polyetherurethane, said method comprising:
- coating, prior to implantation, said heart valve including its leaflets with a coating derived from a compound of the formula:
- X-Y-Z
- wherein X is a photochemically reactive group capable upon activation of bonding to the surface of the heart valve, Y represents nothing or a relatively inert, noninterfering skeletal moiety joining groups X and Z and is resistant to cleavage in aqueous physiological fluids, and Z is a fatty acid moiety, said coating being effective to reduce calcification and thrombus formation after implantation.
A biocompatible heart valve comprising:
- a stent defining a blood flow path;
- and
- a plurality of leaflets comprising a polymer selected from the group consisting of silicone rubber, polyurethane, and polyetherurethane, said leaflets having an applied surface coating effective to render said heart valve resistant to in vivo pathologic thrombus formation and in vivo pathologic calcification, said coating being derived from a compound of the formula
- X-Y-Z
- wherein X is a chemically reactive group capable upon activation of bonding to the surface of the heart valve;
- Y represents nothing or a relatively inert, noninterfering skeletal moiety joining groups X and Z and is resistant to cleavage in aqueous physiological fluids, and Z is a fatty acid moiety.
A method for reducing calcification and thrombus formation in a biocompatible heart valve comprising a polymer selected from the group consisting of silicone rubbers, polyurethane, and polyetherurethane, said method comprising:
- providing a first coat, prior to implantation, to said heart valve including its leaflets, of a first coating derived from a compound of the formula:
- X-Y-Z
- wherein X is a photochemically reactive group capable upon activation of bonding to the surface of the heart valve, Y represents nothing or a relatively inert, noninterfering skeletal moiety joining groups X and Z and is resistant to cleavage in aqueous physiological fluids, and Z is a polyvinylpyrrolidone moiety, and
- providing a second coat, prior to implantation, to said heart valve including its leaflets, of a second coating comprising a hyaluronic acid moiety coupled to said polyvinylpyrrolidone moiety.
A biocompatible heart valve comprising:
- a stent defining a blood flow path;
- and
- a plurality of leaflets comprising a polymer selected from the group consisting of silicone rubber, polyurethane, and polyetherurethane, said leaflets having an applied surface coating effective to render said heart valve resistant to in vivo pathologic thrombus formation and in vivo pathologic calcification, said applied surface coating comprising:
- a first coating derived from a compound of the formula
- X-Y-Z
- wherein X is a chemically reactive group capable upon activation of bonding to the surface of the heart valve;
- Y represents nothing or a relatively inert, noninterfering skeletal moiety joining groups X and Z and is resistant to cleavage in aqueous physiological fluids, and Z is a polyvinylpyrrolidone moiety;
- and
- a second coating comprising a hyaluronic acid moiety coupled to said polyvinylpyrrolidone moiety.
Dependencies are inferred from the claim text.