Npyy5 antagonists
AssigneeShionogi & Co., Ltd.
InventorsYasuyuki Kawanishi, Hideyuki Takenaka, Kohji Hanasaki, Tetsuo Okada
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Abstract
The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, R2 is hydrogen, lower alkyl or the like, n is 1 or 2, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, Y is CONR7, CSNR7, NR7CO, NR7CS or the like, Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like and R7 is hydrogen or lower alkyl, prodrug, pharmaceutically acceptable salt or solvate thereof.
Claims10
A pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula (I):
- wherein R1 is optionally substituted lower alkyl, optionally substituted cycloalkyl or optionally substituted aryl,
- R2 is hydrogen or lower alkyl, and R1 and R2 taken together may form lower alkylene,
- n is 1 or 2, R3, R4, R5 and R6 are each independently hydrogen or lower alkyl,
- is optionally substituted cycloalkylene or optionally substituted bicycloalkylene, and
- p and q are each independently 0 or 1,
- R7 is hydrogen or lower alkyl, and
- Z is optionally substituted pyridyl,
- prodrug, pharmaceutically acceptable salt or hydrate thereof together with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.