Method for treatment of tumors using nucleic acid ligands to PDGF
AssigneeGilead Sciences, Inc.
InventorsKristian Pietras, Arne Östman, Carl-Henrik Heldin, Kristofer Rubin
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Abstract
A method is provided for treating solid tumors comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent. In a preferred embodiment the PDGF aptamer is identified using the SELEX process for the Systematic Evolution of Ligands by Exponential enrichment. A method is also provided for reducing the interstitial fluid pressure (IFP) of a solid tumor comprising administering a PDGF aptamer. Finally, a method is provided for increasing the uptake of cytotoxic agents into a tumor comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent.
Claims11
A method for treating tumors comprising administering to a host having a tumor a therapeutically effective dose of a composition comprising a platelet-derived growth factor (PDGF) aptamer and a cytotoxic agent, whereby tumors are treated.
A method for reducing the interstitial fluid pressure (IFP) of a tumor comprising administering a PDGF aptamer to a host having a tumor, whereby the intestinal fluid pressure of a tumor is reduced.
A method for increasing the uptake of cytotoxic agents into a tumor comprising administering to a host having a tumor a composition comprising a PDGF aptamer and a cytotoxic agent, whereby the uptake of cytotoxic agents into the tumor is increased.
Dependencies are inferred from the claim text.