Vaccine and immunserum against drugs of abuse
OwnerErich Hugo Cernyinventor
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Abstract
Addictive drugs like cocaine, heroin or amphetamines are spreading in an epidemic manner in the western world and are an important factor in the spread of the acquired immune deficiency syndrome AIDS (multiple use of infected needles among drug addicts) the present invention describes a vaccine and immunoserum against drugs. The vaccine contains the drug bound to a carrier protein in order to produce antibodies against the drugs in the affected person. The use of the drug in the presence of the antibodies deactivates the drug. The desired drug effect is thus eliminated and the vicious circle between stimulation and application is broken.
Claims20
A method for the manufacture of an immunogenic preparation for use as a vaccine,
- comprising the step of providing at least one substance linked as a hapten to a carrier substance in order to obtain a conjugate, wherein the hapten is a drug of abuse,
- processing the conjugate by purification and sterile filtration,
- preparing the purified and filtered conjugate in a number of doses in a physiologically acceptable solution,
- so that the cumulative dose of the conjugate per vaccination treatment is in excess of 0 micrograms and does not exceed a total amount of 320 micrograms absorbed by a body
- and induces the lasting protective effect of a vaccine no later than 4 months and over a time span of at least 8 months after the first application of said vaccine, despite repeated drug challenges.
A method for treating and/or preventing with a vaccine a physical or physical and psychological dependence of a subject on a drug of the kind provoking a psychotropic stimulating effect only when a sufficient quantity of said drug, or at least one component of said drug reaches a particular receptor in the human body, said subject having not necessarily been withdrawn from the drug,
- comprising the step of administering to said subject an amount of complex molecules capable of eliciting antibodies against said drug, or said component of said drug, in the human body,
- each of said complex molecules including a carrier substance and at least one molecule selected from said drug and said component of said drug, linked to said carrier as a hapten, wherein the amount of said complex molecules administered in the human body per application is in excess of 0 micrograms and does not exceed a total amount of 320 micrograms absorbed by the body
- and which induces the long lasting protective effect of a vaccine no later than 4 months and over an extended time span of at least 8 months after the first application, despite repeated drug challenges.
A method for activating at least the B-cell branch of the immune system of a mammal against a drug which may cause a dependence in a vaccinated animal having specific antibodies against said drug as a result of a vaccination, so that an administration of said drug to said mammal elicits antibodies in said mammal's body, said method comprising the steps
- of linking a compound selected from said drug and a component of said drug, as a hapten, to a carrier substance having immunogenic properties, thereby synthesizing a hapten carrier conjugate,
- purifying said hapten carrier conjugate,
- providing the purified conjugate in a physiologically acceptable solution in doses containing an effective amount for vaccination by said purified conjugate, and administering said effective amount as the vaccine to said mammal.
A method for treating a physical and/or psychological dependence of a mammal on nicotine containing cigarettes, said method comprising the step
- of administering to said mammal an effective amount of complex molecules capable of eliciting antibodies against nicotine in the mammal's body, each of said complex molecules including at least one molecule of nicotine, linked to a carrier substance as a hapten capable of inducing antibodies against nicotine for treating said physical or physical and psychological dependence.
A method for preventing a physical and/or psychological dependence of a mammal on nicotine containing drugs, which can be smoked, said method comprising the step of
- administering to said mammal an effective amount of complex molecules capable of eliciting antibodies against nicotine in the mammal's body,
- each of said complex molecules including a carrier substance having immunogenic properties and at least one molecule of nicotine, linked to said carrier as a hapten
- in order to prevent a physical and/or psychological dependence of a mammal on nicotine containing smoke.
Dependencies are inferred from the claim text.