Human anti-epidermal growth factor receptor single-chain antibodies
AssigneeThe UAB Research Foundation
InventorsKevin Paul Raisch, David T. Curiel, James Alan Bonner
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Abstract
Human anti-epidermal growth factor receptor (EGFR) single-chain antibodies (scFvs) were isolated from a human IgM phage display library using purified epidermal growth factor receptor as antigen. Two isolates with different amino acid sequences were identified by ELISA as epidermal growth factor receptor-specific. The scFvs bind to the full length epidermal growth factor receptor and the truncated and/or mutated epidermal growth factor receptor on human cells. These anti-EGFR-scFvs are useful as therapeutic and/or diagnostic agents.
Claims7
An isolated human anti-epidermal growth factor receptor single-chain antibody having the sequence of SEQ ID NO:
- 1 or a biologically functional fragment thereof wherein said antibody hinds to the extracellular domain epidermal growth factor receptor.
Dependencies are inferred from the claim text.