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US 6,699,272 B2Granted
Biodegradable polymeric endoluminal sealing process, apparatus and polymeric products for use therein
AssigneeEndoluminal Therapeutics, Inc.
InventorsMarvin J. Slepian, Anton Schindler
Life of this patent
Estimating the term…
Abstract
A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of the lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.
Claims105
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- a radially expandable balloon near the distal end of the shaft;
- a polymeric article, formable into a layer of biodegradable polymeric material in intimate contact with a tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the balloon;
- and
- an emitter of electromagnetic radiation near the distal end of the shaft positioned in optical communication with the polymeric article.
2 more elements
A catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element near the distal end of the shaft;
- and
- a polymeric article that contains a therapeutic agent positioned on the article-forming element, formable into a layer of biodegradable polymeric material in intimate contact with a tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article.
3 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a vessel of a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element near the distal end of the shaft;
- and
- a polymeric article formable into a stent within the vessel when the shaft is inserted into the patient, the polymeric article positioned on the article-forming element, wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article.
2 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a vessel of a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element near the distal end of the shaft;
- and
- a polymeric article formable into a polymeric, non-fluent material able to resist radial compressive forces within the vessel when the shaft is inserted into the patient, the polymeric article positioned on the article-forming element, wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article.
2 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a vessel of a patient and a proximal end adapted to remain outside of the patient;
- a radially expandable balloon near the distal end of the shaft;
- a polymeric article formable into a stent within the vessel when the shaft is inserted into the patient, positioned on the balloon;
- and
- an emitter of electromagnetic radiation near the distal end of the shaft positioned in optical communication with the polymeric article.
2 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a vessel of a patient and a proximal end adapted to remain outside of the patient;
- a radially expandable balloon near the distal end of the shaft;
- a polymeric article formable into a polymeric, non-fluent material able to resist radial compressive forces within the vessel when the shaft is inserted into the patient, positioned on the balloon;
- and
- an emitter of electromagnetic radiation near the distal end of the shaft positioned in optical communication with the polymeric article.
2 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element near the distal end of the shaft;
- and
- a polymeric article positioned on the article-forming element that is formable into a layer of biodegradable polymeric material in intimate contact with a tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article and wherein the article is made of a material selected from the group consisting of polymers of carboxylic acids, polyurethanes, polyesters, polyamides, polyacrylonitriles, polyphosphazines, polylactones, polyanhydrides, polyethylenes, polyvinyl chlorides, ethylene vinyl acetate, delta-valerolactone, and p-dioxanone.
3 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element near the distal end of the shaft;
- and
- a polymeric article that contains living cells, formable into a layer of biodegradable polymeric material in intimate contact with a tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the article-forming element,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article.
3 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- an article-forming element near the distal end of the shaft;
- and
- a polymeric article, formable into a layer of biodegradable polymeric material in intimate contact with a tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the article-forming element,
- wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article and the polymeric article is non-fluent at normal patient temperature, becomes fluent when its temperature is raised above normal patient temperature, and becomes non-fluent when its temperature returns to normal patient temperature.
3 more elements
A catheter apparatus, comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adopted to remain outside of the patient;
- an emitter of electromagnetic radiation near the distal end of the shaft;
- a radially expandable article-forming element near the distal end of the shaft;
- a polymeric article, formable into a layer of biodegradable polymeric material in intimate contact with a tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient, positioned on the article-forming element wherein the emitter of electromagnetic radiation is positioned in optical communication with the polymeric article;
- and
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end, wherein the radially expandable article-forming element is connected via the lumen to a source of pressurized fluid.
3 more elements
A catheter apparatus comprising:
- an elongate tubular shaft having a distal end insertable into a patient and a proximal end adapted to remain outside of the patient;
- a lumen associated with the shaft that provides fluid communication between the distal end and the proximal end;
- a reservoir of pre-polymer fluid in fluid communication with the distal end of the shaft via the lumen that is formable into a layer of biodegradable polymeric material in intimate contact with a tissue surface that is near the distal end of the shaft when the shaft is inserted into a patient;
- and
- an emitter of electromagnetic radiation near the distal end of the shaft.
2 more elements
Dependencies are inferred from the claim text.