Method and compositions for regulation of 5-alpha reductase activity
AssigneeUniversity of Chicago Office of Technology and Intellectual Property
InventorsShutsung Liao, Richard Hiipakka
Life of this patent
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Abstract
Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5α-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catechins, particularly epigallocatechin derivatives, fatty acids, and the salts, esters, analogues, pro-drugs, isomers, racemic mixtures, or derivatives of any of the foregoing. The use of testosterone (or DHT) combinations with the aforementioned 5α-reductase inhibitor compounds is also contemplated.
Claims57
A pharmaceutical composition, comprising:
- a pharmacologically effective amount of at least one 5α-reductase inhibitor composition in a pharmaceutically acceptable vehicle.
A pharmaceutical composition, comprising:
- a pharmacologically effective amount of at least one 5α-reductase inhibitor composition and a pharmacologically effective amount of a testosterone composition in a pharmaceutically acceptable vehicle.
A method of preventing the conversion of dihydrotestosterone to testosterone in the skin of a mammal, comprising:
- administering a testosterone composition to the skin;
- and
- administering a 5α-reductase inhibitor composition to the skin.
A method of arresting or reducing cancer cell growth in a mammal comprising:
- administering a testosterone composition to said mammal;
- and
- administering a 5α-reductase inhibitor composition to said mammal.
A method of reducing weight in a mammal comprising:
- administering a testosterone composition to said mammal;
- and
- administering a 5α-reductase inhibitor composition to said mammal.
A method of inhibiting lipid production in a cell comprising:
- administering a testosterone composition to said cell;
- and
- administering a 5α-reductase inhibitor composition to said cell.
A method of reducing hair loss in a human comprising:
- administering a testosterone composition to said human;
- and
- administering a 5α-reductase inhibitor composition to said human.
A method of treating skin disorders in a human comprising:
- administering a testosterone composition to said human;
- and
- administering a 5α-reductase inhibitor composition to said human.
Dependencies are inferred from the claim text.