Substituted phenyl derivatives, their preparation and use

A compound having the formula

• or a pharmaceutically acceptable salt thereof
• wherein one of R1, R2 and R3 is 3-hydroxy-4- oxo-pyranyl, 2-hydroxy-4-oxo-pyrimidyl, 3,5-dioxo-1,2,4-oxadiazolidinyl, 2,4-dioxo-imidazolidinyl, 2,5-dioxo-3-hydroxy-pyrrolyl 2,5-dioxo-pyrrolidinyl, 2,4-dioxo-1,3-thiazolidinyl, 3-hydroxy-isoxazolyl, 5-hydroxy-isoxazolyl, 3-hydroxy-isothiazolyl, 3 hydroxy-1,2,5thiadiazolyl, tetrazolyl, 3-hydroxy-triazolyl, 3-hydroxy-pyrazolyl, or 2-hydroxy-1,3,4-oxadiazolyl;
• R4, R5 and the other two substituents R1, R2 and R3 are each independently selected from hydrogen;
• alkyl;
• alkoxy;
• hydroxy;
• halogen;
• trifluoromethyl;
• cyano;
• nitro;
• amino;
• alkylamino, NHCOR9, CO2R9, —CON(R9)2, —NHSO2-R9, —SO2N(R9)2 wherein R9 represents hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkyny, aryl, aralkyl, heteroaryl or R9 comprises a 5-8 membered ring optionally containing double bonds and optionally containing one or two heteroatoms, which can be substituted by alkyl or acyl;
• or (R9)2 together with the heteroatom to which it is connected represents a 5-8 membered ring optionally containing double bonds and optionally containing another heteroatom which can be substituted by alkyl or acyl;
• aryl, phenylamino, phenoxy or heteroaryl wherein the phenyl, aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, nitro, amino, NHCOR9, CO2R9, —CON(R9)2, —NHSO2-R9, —SO2N(R9)2 wherein R9 is as defined above;
• or R3 and R4 or R4 and R5 together form a 4-8 membered saturated or unsaturated ring and the other substituents R1, R2, R3, R4 and R5 is as defined above;
• Y represents
• wherein R0 and R00 independently represents hydrogen or lower alkyl;
• X represents O or S;
• R11, R12, R13, R14 and R15 are each independently selected from hydrogen;
• alkyl;
• alkoxy;
• hydroxy;
• halogen;
• trifluoromethyl;
• cyano;
• nitro;
• amino;
• alkylamino;
• —COOR7;
• —NHSO2-alkyl;
• —SO2N(R7)2;
• —SO2OR7;
• —CO—R7;
• aryl, phenylamino, phenoxy or heteroaryl wherein the phenyl, aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, hydroxy, alkoxy, halogen, trifluoromethyl, cyano, nitro, amino and alkylamino, —COOR 7;
• CON(R7)2, —NHSO2—R7;
• —SO2N(R7)2;
• —SO2OR7;
• —CO—R7, or one of R11 and R12, R12 and R13, R13 and R14 and R14 and R15 together form a 4-8 membered saturated or unsaturated ring and the other substituents R11, R12, R13, R14 and R15 is as defined above and wherein R7 represents hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl or R7 comprises a 5-8 membered ring optionally containing double bonds and optionally containing one or two heteroatom which can be substituted by alkyl or acyl;
• or (R7)2 together with the heteroatom to which it is connected represents a 5-8 membered ring optionally containing double bonds and optionally containing another heteroatom which can be substituted by alkyl or acyl.