Chimeric flavivirus vaccines
AssigneesAcambis Inc., St. Louis University
InventorsThomas J. Chambers, Thomas P. Monath, Farshad Guirakhoo
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Abstract
A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
Claims9
A chimeric live, infectious, attenuated virus, comprising a yellow fever virus in which the nucleotide sequences encoding the pre-membrane and envelope proteins are replaced with the nucleotide sequences encoding pre-membrane and envelope proteins of a Dengue virus.
Dependencies are inferred from the claim text.