Candida geranylgeranyl-protein transferase polypetide, compositions and methods related thereto
AssigneeGPC Biotech AG
InventorsVivian Berlin, Veronique Damagnez, Susan E. Smith
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Abstract
The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis. Another aspect of the present invention relates to novel Candida genes and gene products.
Claims11
An isolated or recombinant geranylgeranyl protein transferase (GGPTase) polypeptide comprising a sequence at least 90% identical to SEQ ID NO:
- 8, which polypeptide directs the binding of said polypeptide to other GGPTase subunit(s) or to a Rho1-like GTPase, or a combination thereof.
An isolated or recombinant geranylgeranyl protein transferase (GGPTase) polypeptide encodable by a nucleic acid which specifically hybridizes under stringent conditions of 6.0× sodium chloride/sodium citrate (SSC) at about 45° C. followed by a wash of 0.2×SSC at about 65° C., to the sequence of SEQ ID NO:
- 7, wherein the polypeptide possesses GGPTase activity and directs the binding of said polypeptide to other GGPTase subunit(s) or to a Rho1-like GTPase, or a combination thereof.
Dependencies are inferred from the claim text.