Systemic immune activation method using nucleic acid-lipid complexes
AssigneeNational Jewish Medical and Research Center
InventorsSteven W. Dow, Robyn E. Elmslie, Jürgen Karl Johannes Schwarze
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Abstract
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, or an infectious disease. Also disclosed are therapeutic compositions useful in such a method.
Claims18
A composition for the elicitation of a systemic, non-antigen specific immune response in a mammal comprising:
- a. a cationic liposome delivery vehicle;
- and;
- b. an isolated nucleic acid molecule selected from the group consisting of:
- i. an oligonucleotide comprising a CpG motif;
- and
- ii. an isolated bacterially-derived nucleic acid vector without a gene insert, or a fragment thereof;
- wherein said therapeutic composition elicits a systemic, non-antigen-specific immune response in said mammal.
A method for eliciting a systemic, non-antigen specific immune response in a mammal, comprising administering to said mammal an amount of a composition effective to elicit said immune response, wherein said composition comprises:
- a. a cationic liposome delivery vehicle;
- and;
- b. an isolated nucleic acid molecule selected from the group consisting of:
- i. an oligonucleotide comprising a CpG motif;
- and
- ii. an isolated bacterially-derived nucleic acid vector without a gene insert or a fragment thereof.
Dependencies are inferred from the claim text.