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US 6,692,960 B2Granted
Antisense modulation of sphingosine-1-phosphate lyase expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsC. Frank Bennett, Susan M. Freier
Life of this patent
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of sphingosine-1-phosphate lyase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sphingosine-1-phosphate lyase. Methods of using these compounds for modulation of sphingosine-1-phosphate lyase expression and for treatment of diseases associated with expression of sphingosine-1-phosphate lyase are provided.
Claims14
A compound up to 50 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 13, 15, 16, 18, 19, 20, 21, 22, 26, 28, 29, 33, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 58, 59, 60, 63, 64, 65, 66, 67, 68, 72, 73, 74, 77, 78, 79, 80, 81, 82, 84, 85, 87 or 89 which inhibits the expression of sphingosine-1-phosphate lyase.
A compound consisting of SEQ ID NO:
- 27 or 55.
Dependencies are inferred from the claim text.