Inhibition of a target messenger RNA with a modified U1 small nuclear RNA
AssigneeUniversity of Connecticut
InventorsDavid W. Rowe, Mary Louise Stover, Akin Beckley
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Abstract
Methods of reducing gene expression, protein production and messenger RNA output in a cell are disclosed. Also disclosed is a method for delivering a selected ribozyme to a target mRNA in a cell. The methods are useful for prophylactic and therapeutic purposes.
Claims3
A nucleic acid construct comprising a U1 snRNA, wherein the U1 snRNA is modified so that it is complementary to a preselected nucleotide sequence in a target nucleic acid, wherein the preselected nucleotide sequence is in a terminal (3′) exon of the target nucleic acid, said U1 snRNA being modified at a 5′ end to render the construct complementary to the preselected nucleotide sequence.
Dependencies are inferred from the claim text.