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US 6,692,724 B1Granted
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
AssigneeBoard of Regents, The University of Texas System
InventorsDavid J. Yang, Chun W. Liu, Dong-Fang Yu, E. Edmond Kim
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Abstract
The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
Claims22
A composition for imaging comprising:
- a) a radionuclide label;
- b) ethylenedicysteine;
- and
- c) a tissue specific ligand conjugated to said ethylenedicysteine, wherein the tissue specific ligand is an anticancer agent, a folate receptor targeting ligand, a tumor apoptotic cell targeting ligand, a tumor hypoxia cell targeting ligand or glutamate pentapeptide;
- and wherein said ethylenedicysteine forms an N2S2 chelate with said radionuclide label.
2 more elements
Dependencies are inferred from the claim text.