Back to results
US 6,692,456 B1Granted
Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
AssigneeAltea Therapeutics Corporation
InventorsJonathan A. Eppstein, Michael R. Hatch, Joseph Papp
Life of this patent
Estimating the term…
Abstract
The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.
Claims53
A microporation device, comprising:
- at least one reservoir and
- a tissue interface comprising probe elements and a substrate,
- wherein the probe elements located on or within the substrate and
- further comprising diodes for isolating the electrical circuits used for activating the probe elements.
1 more element
A microporation device, comprising:
- at least one reservoir comprising multiple chambers and
- a tissue interface comprising at least one microporator and a substrate,
- wherein the microporator is located on or within the substrate and
- wherein the multiple chambers comprise at least first and second chambers, said first chamber comprises a first substance and said second chamber comprises a second substance.
1 more element
A microporation device, comprising:
- at least one reservoir and
- a tissue interface comprising at least one microporator and a substrate, wherein the microporator is located on or within the substrate,
- said microporation device further comprising a disposable component,
- wherein the disposable component comprises stimuli-responsive polymer gel sections comprising a material that is released by a thermal, chemical or electrical stimulus.
1 more element
A method for forming openings in a biological membrane, comprising:
- placing a microporation device in close proximity of the biological membrane and triggering the microporation device to form at least one opening in the biological membrane, the microporation device, comprising:
- at least one reservoir and a tissue interface comprising at least one microporator and a substrate, wherein the microporator is located on or within the substrate, said method further comprising mixing a substance prior to delivery of a substance into the biological membrane.
Dependencies are inferred from the claim text.