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US 6,689,558 B2Granted
Cells for drug discovery
AssigneeSangamo BioSciences, Inc.
InventorCasey Case
Life of this patent
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Abstract
Disclosed herein are compositions and method useful in screening a compound for its interaction and/or effect with a molecular target and/or cellular process.
Claims22
A method of screening a compound for interaction with a molecular target comprising:
- (a) contacting a first cell with the compound;
- (b) determining a first value of a property of the first cell, the property being responsive to, levels of the molecular target;
- (c) contacting a second cell with the compound, wherein the second cell comprises a polynucleotide encoding an exogenous zinc finger protein that directly or indirectly modulates expression of the molecular target;
- (d) determining a second value of the property in the second cell, wherein a difference between the first and second values provides an indication of interaction between the compound and the molecular target.
1 more element
Dependencies are inferred from the claim text.