Immunodominant human T-cell epitopes of hepatitis C virus
AssigneeInnogenetics N.V.
InventorsGeert Leroux-Roels, Robert Deleys, Geert Maertens
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Abstract
The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids containing a T-cell stimulating epitope.
Claims66
An isolated peptide consisting of SEQ ID NO:
- 57.
An isolated peptide consisting of the an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 135-147 and 149-162.
An isolated peptide consisting of at least 8 to at most 20 contiguous amino acids of a sequence selected from the group consisting of SEQ ID NOs:
- 135-147, 149 and 152-162.
A method of inducing a specific T cell function comprising administering to a person a polypeptide consisting of at least 8 to at most 278 contiguous amino acids of the amino acid sequence represented by SEQ ID NO 57, in an amount sufficient to induce T cell activity and said contiguous amino acids containing a T cell-stimulating epitope.
An isolated peptide consisting of at least 8 to at most 15 contiguous amino acids of SEQ ID NO:57, wherein an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 150 and 151 is present in said peptide.
An isolated peptide consisting of at least 8 to at most 20 contiguous amino acids of SEQ ID NO:57, wherein SEQ ID NO:
- 155 is present in said peptide.
An isolated peptide consisting of at least 8 to at most 25 contiguous amino acids of SEQ ID NO:57, wherein at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
- 149, 158, and 159 is present in said peptide.
An isolated peptide consisting of at least 8 to at most 30 contiguous amino acids of SEQ ID NO:57, wherein at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
- 139, 142, 143, 144, 145, 146, 156, and 157, is present in said peptide.
An isolated peptide consisting of at least 8 to at most 80 contiguous amino acids of the peptide of SEQ ID NO:57, wherein at least one peptide selected from the group consisting of SEQ ID NOs:
- 140 and 162, is present in said peptide.
An isolated peptide consisting of at least 8 to at most 278 contiguous amino acids of SEQ ID NO:57, wherein said peptide includes at least one amino acid sequence selected from the group consisting of SEQ ID NOs:
- 135, 136, 137, 138, 141, 147, 152, 153, 154, 160 and 161.
An isolated peptide consisting of at least 9 to at most 25 contiguous amino acids of SEQ ID NO:57, wherein said peptide includes SEQ ID NO:148.
Dependencies are inferred from the claim text.