Therapeutic polyesters and polyamides
AssigneeRutgers, The State University of New Jersey
InventorKathryn E. Uhrich
Life of this patent
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Abstract
A polymer which comprises one or more units of formula (II) in the backbone: —R2—A—L—A—R3—A—L—A— (II) wherein R2 and R3 are each independently a group that will yield a biologically active compound upon hydrolysis of the polymer; each A is independently an amide or ester linkage; and each L is independently a linking group. Methods of producing these polymer, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided.
Claims20
A polymer which comprises one or more units of formula (II) in the backbone:
- —R2—A—L—A—R3—A—L—A— (II)
- wherein
- R2 and R3 are each independently a group that will yield a nonsteroidal anti-inflammatory drug upon hydrolysis of the polymer;
- each A is independently an amide or ester linkage;
- and
- each L is independently a linking group.
A polymer which comprises one or more units of formula (II) in the backbone:
- —R2—A—L—A—R3—A—L—A— (II)
- wherein
- R2 and R3 are each independently a group that will yield a nonsteroidal anti-inflammatory drug upon hydrolysis of the polymer;
- each A is independently an amide or ester linkage;
- each L is independently a linking group;
- and
- wherein a therapeutic agent is dispersed in the matrix of the polymer.
A polymer which comprises one or more units of formula (II) in the backbone:
- —R2—A—L—A—R3—A—L—A— (II)
- wherein
- R2 and R3 are each independently a group that will yield a nonsteroidal anti-inflammatory drug upon hydrolysis of the polymer;
- each A is independently an amide or ester linkage;
- each L is independently a linking group;
- and
- wherein a therapeutic agent is appended to the polymer backbone.
A method for producing a biocompatible and biodegradable polyester or polyamide which degrades into a nonsteroidal anti-inflammatory drug comprising co-polymerizing a biologically active compound containing at least two alcohol or phenol groups or at least two amine groups with carboxylic acid groups or bis(acyl) chlorides.
Dependencies are inferred from the claim text.