Methods and apparatus for intraluminal deposition of hydrogels

An apparatus for use in delivering compositions for sealing a puncture that passes through a patient's skin and through a wall of a lumen of an artery or vein of the patient, the apparatus comprising:

• a delivery device comprising a fist and a second inlet port and a first and a second outlet, with a first delivery device conduit fluidly coupling the first inlet port to the first outlet port and a second delivery device conduit coupling the second inlet port to the second outlet port;
• and,
• an occlusive element having a nonsealing position and a sealing position, with the occlusive element being adapted to seal against the luminal wall of the artery or vein in the sealing position such that the artery or vein lumen is sealed off from the puncture;
• wherein the delivery system is adapted to be positioned with the two inlet ports outside of the patient while the two outlets open into the puncture and the occlusive element is in the sealing position.

A system for sealing a puncture that passes through a patient's skin and through a wall of a lumen of an artery or vein of the patient, the apparatus comprising:

• a delivery device comprising two inlet ports adapted to receive fluid into the delivery device and at least one outlet adapted to allow fluid received into the delivery device via at least one of the inlet ports to exit the delivery device;
• a first vessel fluidly connected to one of the two inlet ports and a second vessel fluidly connected to the other of the two inlet ports, with the first vessel holding a first prepolymer comprising at least two functional groups chosen from the group consisting of amines and thiols and the second vessel holding a second prepolymer comprising polyethylene glycol and having at least two groups that demonstrate covalent bonding activity with the functional groups of the first prepolymer;
• and
• an occlusive element having a nonsealing position and a sealing position, with the occlusive element being adapted to seal against the luminal wall of the artery or vein in the sealing position such that the lumen is sealed off from the puncture;
• wherein the delivery system is adapted to be positioned with the two inlet ports outside of the patient while the outlet opens into the puncture and the occlusive element is in the sealing position with the two prepolymers being crosslinkable with each other to form a crosslinked structure.

An apparatus for sealing a puncture that passes through a patient's skin and through a wall of a lumen of an artery or vein of the patient, the apparatus comprising:

• means for sealing the luminal wall of the artery or vein;
• means for containing a first prepolymer comprising at least two functional groups chosen from the group consisting of amines and thiols;
• means for containing a second prepolymer comprising polyethylene glycol and having covalent bonding means for covalently bonding to the functional groups of the first prepolymer;
• and
• means for delivering the first and the second prepolymers into the puncture when the means for sealing has sealed off the lumen of the artery or vein from the puncture.

A method of sealing a puncture that passes through a patient's skin and through a wall of a lumen of an artery or vein of the patient, the method comprising:

• providing a delivery system comprising two inlet ports adapted to receive fluid into the delivery device;
• at least one outlet adapted to allow fluid received through at least one of the two inlet ports to exit the delivery device, and an occlusive element having a nonsealing position and a sealing position, with the occlusive element being adapted to seal against the luminal wall of the artery or vein in the sealing position such that the lumen is sealed off from the puncture;
• positioning the delivery system with the two inlet ports outside of the patient with the outlet opening into the puncture while the occlusive element is in the sealing position,
• introducing a first prepolymer comprising at least two functional groups chosen from the group consisting of amines and thiols into one of the two inlet ports;
• and introducing into the other inlet port a second prepolymer comprising polyethylene glycol and having at least two groups that demonstrate covalent bonding activity with the functional groups of the first prepolymer with the two prepolymers being crosslinkable with each other to form a crosslinked structure.

A kit for sealing a puncture that passes through a patient's skin and through a wall of a lumen of an artery or vein of the patient, the kit comprising:

• a delivery device comprising two inlet ports adapted to receive fluid into the delivery device and at least one outlet adapted to allow fluid received into the delivery device via at least one of the inlet ports to exit the delivery device;
• a first prepolymer comprising at least two functional groups chosen from the group consisting of amines and thiols and a second prepolymer comprising polyethylene glycol and having at least two groups that demonstrate covalent bonding activity with the functional groups of the first prepolymer;
• an occlusive element adapted to cooperate with the delivery device to seal against the luminal wall of the artery or vein such that the lumen is sealed off from the puncture;
• wherein the delivery system is adapted to be positioned with the two inlet ports outside of the patient while the outlet opens into the puncture and the occlusive element is in the sealing position with the two prepolymers being crosslinkable with each other to form a crosslinked structure.