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US 6,686,499 B1Granted
Method for making 2-(N-phenylamino)benzoic acids
AssigneeWarner-Lambert Company
InventorsMichael Huai Gu Chen, Javier Magano
Life of this patent
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Abstract
The present invention relates to a method for making 2-N-phenylamino)benzoic acids by coupling a benzoic acid and an aniline using an alkaline metal hexamethyldisilazide as a base.
Claims10
A method for making 2-(N-phenylainino)benzoic acids, the method comprising the step of reacting a benzoic acid having the Formula I
- and an aniline having the Formula II
- with an alkaline metal hexamethyldisilazide to form a 2-(N-phenylamino)benzoic acid having the Formula III
- wherein
- each R is independently hydrogen, halogen, C1-C6alkyl, —OC1-C6 alkyl, CN, or NO2.
1 more element
The method of claim l wherein the alkaline metal hexamethyldisilazide is about 3 equivalents or more with respect to the benzoic acid.
Dependencies are inferred from the claim text.