Immunosuppressive agents that inhibit calcineurin function and uses of these agents
AssigneeMassachusetts Institute of Technology
InventorsJun O. Liu, Luo Sun, Hong-Duk Youn
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Abstract
The present invention provides novel immunosuppressive agents. In particular, the invention provides immunosuppressive agents that bind calcineurin and/or that inhibit interaction between calcineurin and NF-AT. The invention also provides analogs of these agents, nucleic acids encoding the agents and/or their analogs, gene therapy vectors, etc., and methods of making and using them.
Claims9
An isolated polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:1.
A polypeptide produced by a method comprising expressing a nucleic acid encoding the amino acid sequence as set forth in SEQ ID NO:1, and recovering said polypeptide.
A polypeptide produced by a method comprising expressing a nucleic acid encoding the amino acid sequence as set forth in SEQ ID NO:2, SEQ ID NO:3, SEQ ED NO:4, SEQ ID NO:5, SEQ ID NO:6 or SEQ ID NO:7.
Dependencies are inferred from the claim text.