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US 6,686,449 B2Granted
Mutant presenilin 1 polypeptides
AssigneePharmacia & Upjohn Company
InventorsDonald Bainbridge Carter, Alfredo Giuseppe Tomasselli
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Abstract
The present invention provides mutant presenilin 1 and presenilin 2 polpeptides and polynucleotides encoding the polypeptides and methods for their production by recombinant and PCR techniques are disclosed. Methods for utilizing the mutant polypeptides in screens for inhibitors of activity are also disclosed.
Claims5
An isolated mutant presenilin-1 polypeptide comprising SEQ ID NO:
- 5 wherein residue 386 is selected from the group consisting of threonine or conservative substitutions of threonine and wherein residue 387, is selected from the group consisting of glycine or conservative substitutions of glycine and wherein said mutant presenilin-1 polypeptide preferentially modulates the processing of amyloid precursor protein to yield increased levels of Aβ1-42 relative to Aβ1-40 when compared to a wild type presenilin-1 polypeptide.
Dependencies are inferred from the claim text.