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AssigneeThe Regents of the University of California
InventorsTimothy J. Deming, Miaoer Yu, Scott A. Curtin, Jungyeon Hwang, Michael D. Wyrsta, Andrew Nowak, Scott W. Seidel
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Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.
A method of preparing a mixture containing an intermediate in combination with a solvent, wherein said intermediate is useful for making polypeptides, said method comprising reacting an NCA monomer with an initiator molecule in a suitable solvent to form the mixture containing the intermediate,
A method for preparing a polypeptide comprising:
A method for preparing a mixture which contains a polypeptide in combination with a solvent, said method comprising:
Dependencies are inferred from the claim text.