2′-substituted 1,1′-biphenyl-2-carboxamides, process for their preparation, their use as medicaments, and pharmaceutical preparations comprising them

A compound of the formula I,

• in which:
• R(1) is SO2R(10) or COR(11);
• R(10) and R(11) are, independently of one another, defined as R(9);
• R(9) is CxH2x—R(14);
• x is 0, 1, 2, 3 or 4
• R(14) is cycloalkyl having 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbon atoms phenyl, naphthyl or biphenylyl,
• where phenyl, naphthyl and biphenylyl are unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
• R(2) is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or CF3;
• R(3) is CyH2y—R(16);
• y is 0, 1, 2, 3 or 4,
• R(16) is cycloalkyl having 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbon atoms, phenyl or naphthyl,
• where phenyl and naphthyl are unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
• R(4) is hydrogen, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or CF3;
• R(5), R(6), R(7) and R(8)
• independently of one another are hydrogen, F, Cl, Br, I, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl or methylsulfonylamino;
• and
• R(30) and R(31)
• independently of one another are hydrogen or alkyl having 1, 2 or 3 carbon atoms;
• or a pharmaceutically acceptable salt thereof.