2,3-dihydrobenzofuran derivatives
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsAkira Ishikawa, Yoshiaki Kato, Kunio Tamura, Yoshiaki Takashima, Osamu Cynshi
Life of this patent
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Abstract
2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R1 represents a hydrogen atom or an acyl group; R2, R3 and R4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or sulfur atoms, provided that R2 and R3 can not simultaneously represent a t-butyl group, or optically active isomers or pharmaceutically acceptable salts thereof are useful as therapeutic or prophylactic agents for various renal diseases and as organ preservatives.
Claims23
A compound of formula (1):
- wherein
- R1 represents a hydrogen atom or an optionally substituted acyl group,
- R2, R3 and R4, which may be identical or different, each represents a hydrogen atom, a lower alkyl group or a lower alkenyl group, provided that one or the other of R2 and R3, but not both simultaneously, is t-butyl, and that R2 is not sec-butyl when R3 is t-butyl, and
- R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or sulfur atoms,
- or an optically active isomer or a pharmaceutically acceptable salt thereof.
A method of treating renal diseases comprising administering to a patient having a renal disease an effective amount of a compound of the formula (1):
- wherein
- R1 represents a hydrogen atom or an optionally substituted acyl group,
- R2, R3 and R1, which may be identical or different, each represents a hydrogen atom, a lower alkyl group or a lower alkenyl group, provided that one or the other of R2 and R3, but not both simultaneously, is t-butyl, and that R2 is not sec-butyl when R3 is t-butyl, and
- R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or sulfur atoms,
- or an optically active isomer or a pharmaceutically acceptable salt thereof.
A method of preserving organs comprising storing an organ in an organ preservative containing an effective amount of a compound of formula (1):
- wherein
- R1 represents a hydrogen atom or an optionally substituted acyl group,
- R2, R3 and R4, which may be identical or different, each represents a hydrogen atom, a lower alkyl group or a lower alkenyl group, provided that one or the other of R2 and R3, but not both simultaneously, is t-butyl, and that R2 is not sec-butyl when R3 is t-butyl, and
- R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or sulfur atoms,
- or an optically active isomer or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.