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US 6,686,384 B2Granted
Substituted benzimidazoles, processes for their preparation, their use as medicaments, and medicaments comprising them
AssigneeAventis Pharma Deutschland GmbH
InventorsArmin Hofmeister, Uwe Heinelt, Hans-Jochen Lang, Markus Bleich, Klaus Wirth, Michael Gekle
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Abstract
The invention relates to the use of compounds of formula I for the production of a medicament for the treatment of illnesses which can be influenced by inhibition of the Na+/H+ exchanger, and to a medicament comprising them: in which R1 to R9 have the meanings shown in the claims.
Claims15
A compound selected from:
- 2-(2,6-dichlorophenylamino)-1H-benzimidazol-4-ol;
- (1H-benzimidazol-2-yl)-(2-chloro-6-methylphenyl)amine;
- (2,6-dichlorophenyl)-(5,6-difluoro-1H-benzimidazol-2-yl)amine;
- (2,6-dichlorophenyl)-(4-methyl-1H-benzimidazol-2-yl)amine;
- (1H-benzimidazol-2-yl)-(2-chloro-6-fluorophenyl)amine;
- (1H-benzimidazol-2-yl)-(2,6-dibromophenyl)amine;
- 2-(2,6-dichlorophenylamino)-5-fluorobenzimidazole;
- 2-(2,6-dichlorophenylamino)-4-fluorobenzimidazole;
- 2-(2-trifluoromethyl-6-chlorophenylamino)benzimidazole;
- 2-(2,6-dichlorophenylamino)-4,5-difluorobenzimidazole;
- 2-(2,6-dichlorophenylamino)-5 hydroxybenzimidazole;
- 2-(2,6-dichlorophenylamino)-4,5,6,7-tetrafluorobenzimidazole;
- or
- 2-(2,6-dichlorophenylamino)-4,6-difluorobenzimidazole;
- or
- a pharmaceutically tolerable salt or trifluoroacetate thereof.
13 more elements
Dependencies are inferred from the claim text.