Prophylactic or therapeutic drug for renal diseases
AssigneeTakeda Chemical Industries, Ltd.
InventorsKohei Nishikawa, Yumiko Shibouta, Keiji Kubo
Life of this patent
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Abstract
This invention relates to methods for the prophylaxis or treatment of diabetic nephropathy comprising, administering as an active ingredient, a compound, or salt thereof, of formula (I) wherein R1 stands for H or lower alkyl; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring; Y stands for a bond, —O—, —S(O)m— wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group).
Claims16
A method for the prophylaxis or treatment of diabetic nephropathy in a mammal comprising the step of administering a pharmaceutically effective amount of a compound or salt thereof represented by formula (I):
- wherein
- R1 stands for H or a lower (C1-C4) alkyl;
- R2 stands for a group represented by the formula —CO—D″ where D″ stands for hydroxy or a lower (C1-C4) alkoxy group, the alkyl moiety of which optionally is substituted with hydroxy, amino, halogen, lower (C2-C6) alkanoyloxy, lower (C4-C7) cycloalkanoyloxy, lower (C1-C6) alkoxycarbonyloxy, lower (C3-C7) cycloalkoxycarbonyloxy or lower (C1-C4) alkoxy;
- R3 stands for a tetrazolyl, carboxyl group or a group represented by the formula
- where i stands for —O— or —S— and j stands for >C═O, >C═S or >S(O)m where m is 0, 1 or 2;
- n stands for 1 or 2;
- ring A stands for a benzene ring;
- Y stands for O, N(H) or S,
- to a mammal in need thereof.
Dependencies are inferred from the claim text.