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US 6,686,381 B2Granted
Thiazole derivatives
AssigneeHoffmann-La Roche Inc.
InventorsPatrizio Mattei, Werner Neidhart, Matthias Heinrich Nettekoven, Philippe Pflieger, Sven Taylor
Life of this patent
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Abstract
Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance disclosed in the specification, and can be used for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
Claims22
A compound of formula I
- wherein
- R1 is aryl or heteroaryl;
- R2 is hydrogen, alkyl or cycloalkyl;
- R3 is hydrogen, alkyl or cycloalkyl;
- R4 is hydrogen, alkyl or cycloalkyl;
- R5 is alkyl, cycloalkyl, aryl, heteroaryl;
- R6 is hydrogen, alkyl or cycloalkyl;
- A is —C(O)—;
- —S(O)2—;
- —N(R6)—C(O)— or —O—C(O)—;
- n is 2 to 6;
- m is zero to 2;
- and pharmaceutically acceptable salts and esters thereof.
10 more elements
Dependencies are inferred from the claim text.