Pyrazoloquinolinone derivatives as protein kinase C inhibitors

A compound of the formula (I):

• or the pharmaceutically acceptable salts thereof wherein
• the dashed lines represent optional double bonds;
• R1 is C1-4 alkyl;
• R2 is H, amino, mono- or di-(C1-4alkyl)amino or C1-3 alkyl-(O═)CNH—;
• R3 is H, halo-CH2—, R4(R5)NCH2—, R6(R7)NC(═O)CH2—, cyano-CH2—, Q1CH2—, Q1-(O═)CCH2—, C2-8 alkyl or Q1-, wherein said C2-8 alkyl is optionally substituted with up to 3 substituents selected from halo, C1-3 alkyl, R4(R5)N, C1-4 alkylsulfonylamino, C1-4 alkylthio, R6(R7)NC(═O)—, cyano, Q1-, Q1-(O═)C— and Q1-C1-4 alkyl-O—;
• Y1, Y2, Y3 and Y4 are independently selected from hydrogen, halo, C1-4 alkyl, C1-4 alkyl-O—, C1-4 alkylthio, Q1-, R6(R8)N—, R6N(R7)C(═O)—, C1-4alkyl-O(O═)CCH═CH—, Q1-(O═)CNH— and R6OC(═O)—, wherein said C1-4alkyl is optionally substituted with up to 2 substituents selected from Q1, Q2-, R6(R7)N—, cyano, hydroxy and R6(R7)NC(═O)—;
• Y5, Y6, Y7 and Y8 are hydrogen or are absent;
• C1, C2, C3 and C4 are carbon atom;
• R4 is H, C1-7 alkyl, HO—C1-4 alkyl, Q1-, Q1-C1-4alkyl-, cyano- C1-4 alkyl- or R6(R7)N C1-4 alkyl-;
• R5 is H, C1-7alkyl, HO—C1-4 alkyl or Q1-;
• R6 and R7 are independently selected from H and C1-4 alkyl
• R8 is aryl or heteroaryl;
• Q1 is a 4-12 membered monocyclic or bicyclic aromatic, partially saturated or fully saturated ring optionally containing up to 4 heteroatoms selected from O, N and S, and is optionally substituted with halo, C1-4 alkyl, amino, hydroxy, R6(R7)NC1-4alkyl- or R6(R7)NC1-4alkyl-O—;
• and
• Q2 is a 5-12 membered monocyclic or bicyclic aromatic, partially saturated or fully saturated ring optionally containing up to 3 heteroatoms selected from O, N and S, and is optionally substituted with halo, C1-4alkyl-, hydroxy, C1-4 alkoxy, nitro, amino, cyano, R6(R7)N—C1-4alkyl-, R6(R7)N—C1-4alkyl-O—, R6(R7)N(O═)C— or R6O(O═)C—;
• with the proviso that when R1 is methyl and R2 and R3 are H, Y1, Y2, Y3 and Y4 are not H simultaneously;
• and when R1 is methyl and R2 and R3 are H, Y2 is not chloro.