Non-steroidal, tetracylic compounds for estrogen-related treatments

A compound having formula II:

• wherein,
• one of Ra or Rb is 'Re and the other is H;
• Re and 'Re are OH, optionally independently etherified or esterified;
• R1 is, halogen, CN, optionally substituted aryl, (1C-4C)alkyl, (2C-4C)alkenyl, (2C-4C)alkynyl or (3C-6C)cycloalkyl, which alkyl, alkenyl, alkynyl and cycloalkyl groups can optionally be substituted with one or more halogens;
• Z is —C(R3,'R3)— or —C(R4,'R4)—C(R5, 'R5)—, wherein R3, 'R3, R4, 'R4, R5, and 'R5, independently are H, (1C-4C)alkyl, (2C-4C)alkenyl or (3C-6C) cycloalkyl, which alkyl, alkenyl and cycloalkyl groups can optionally be substituted with one or more halogens.

A compound having Formula V:

• wherein,
• Re and 'Re are OH, optionally independently etherified or esterified;
• Z is —C(R3,'R3)— or —C(R4,'R4)—C(R5,'R5)—, wherein R3, 'R3, R4, 'R4, R5, and 'R5, independently are H, (1C-4C)alkyl, (2C-4C)alkenyl or (3C-6C) cycloalkyl, which alkyl, alkenyl and cycloalkyl groups can optionally be substituted with one or more halogens;
• R2 is H, halogen, CN, optionally substituted aryl, (1C-4C)alkyl, (2C-4C)alkenyl, (2C-4C)alkynyl, (3C-6C)cycloalkyl, which alkyl, alkenyl, alkynyl and cycloalkyl groups can optionally be substituted with one or more halogens.

A compound having Formula VT:

• wherein,
• one of Ra or Rb is 'Re and the other is H;
• Re and 'Re are OH, optionally independently etherified or esterified;
• R1 and R2 independently are H, halogen, CN, optionally substituted aryl, (1C-4C)alkyl, (2C-4C)alkenyl, (2C-4C)alkynyl or (3C-6C)cycloalkyl, which alkyl, alkenyl, alkynyl and cycloalkyl groups can optionally be substituted with one or more halogens;
• Z is —C(R3,'R3)— or —C(R4,'R4)—C(R5,'R5)—, wherein R3, 'R3, R4, 'R4, R5, and 'R5, independently are H, (1C-4C)alkyl, (2C-4C)alkenyl or (3C-6C) cycloalkyl, which alkyl, alkenyl and cycloalkyl groups can optionally be substituted with one or more halogens.