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US 6,686,370 B2Granted
Triazospiro compounds having nociceptin receptor affinity
AssigneeEuro-Celtique S.A.
InventorsDonald Kyle, R. Richard Goehring
Life of this patent
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Abstract
Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
Claims9
A compound selected from the group consisting of
- 8-[1-(1,2,3,4tetrahydronaphthyl)-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-(1,2,3,4tetrahydronaphthyl)-1-carbonyl-methyl]-3[1-oxo-ethyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-benzodioxane-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-(2-quinoline-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-dibenzocycloheptyl-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-(2-pyridyl)-1-carbonyl-methyl-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[4-phenyl-α-carbonyl-benzyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[4-benzyloxy-α-carbonyl-benzyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-(2-naphthyl)-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[4-trifluoromethyl-α-carbonyl-benzyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-benzylpiperazine-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-decalin-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[α-carbonyl-furfuryl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- and pharmaceutically acceptable salts thereof.
11 more elements
A compound selected from the group consisting of
- 8-[3,3-Bis(phenyl)-4-oxo-butyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-benzodioxane-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-quinoline-methyl-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-phenyl-benzyl-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-benzyloxybenzyl-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-trifluoromethylbenzyl-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-benzylpiperazine-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-nitrofurfuryl-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8[1,4dimethylpentyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8[3-oxo-5-phenyl-1,2cyclohexene]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-fufuryl-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one and pharmaceutically acceptable salts thereof.
8 more elements
A compound selected from the group consisting of
- 8-[4,4-Bis(p-fluorophenyl)-3-carbonyl-butyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[3,3-Bis(phenyl)-2-carbonyl-propyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[1-propylcyclohexyl-1-carbonyl-methyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- 8-[2-phenyl-1-carbonyl-ethyl]-1-phenyl-1,3,8-triazospiro[4.5]decan-4-one;
- and pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.