Bicyclic amino-pyrazinone compounds

A compound of formula (I):

• wherein
• R1 represents hydrogen, or linear or branched (C1-C6)alkyl optionally substituted by one or more identical or different groups selected from aryl, heteroaryl, cycloalkyl and heterocycloalkyl,
• represents a saturated ring having from 4 to 7 ring members that may contain, in addition to nitrogen, one or two hetero atoms selected from O, S and —NR3, wherein R3 represents hydrogen or linear or branched (C1-C6)alkyl,
• n represents an integer such that 1≦n≦6,
• R2 is selected from of the following groups:
• wherein:
• X represents CH or nitrogen,
• R4 represents hydrogen or halogen,
• R5 represents any one of the groups:
• RaNHCOHN— wherein Ra represents hydrogen or linear or branched (C1-C6)alkyl,
• RbSO2NHCO(NH)p—, wherein Rb represents linear or branched (C1-C6)alkyl and p represents 0 or 1,
• HON═C(NH2)—, HN═C(NHOH)—,
• Rc—(CH2)m—Y— wherein:
• Y represents CH2, O, S or RaN, m represents a integer such that 0≦m≦3, Rc represents a saturated or unsaturated heterocycle having 5 or 7 ring members containing from 1 to 4 hetero atoms selected from oxygen, nitrogen and sulphur, the heterocycle optionally containing one or more carbonyl functions and optionally being substituted by one or more identical or different substituents selected from halogen atoms, linear or branched (C1-C6)alkyl groups, linear or branched (C1-C6)alkoxy groups, and amino groups (optionally substituted by one or two linear or branched (C1-C6)alkyl groups), and
• c:
• a bicyclic system of formula
• wherein:
• X is as defined hereinbefore and B, together with the carbon atoms to which it is attached, forms an aryl or a saturated or unsaturated heterocycle having 5 or 7 ring members containing from 1 to 4 hetero atoms selected from oxygen, nitrogen and sulphur, the heterocycle optionally containing at least one carbonyl function and optionally being substituted by one or more identical or different substituents selected from halogen atoms, linear or branched (C1-C6)alkyl groups, linear or branched (C1-C6)alkoxy groups, and amino groups (optionally substituted by one or two linear or branched (C1-C6)alkyl groups),
• its isomers, N-oxides and pharmaceutically acceptable addition salts thereof with an acid or a base, it being understood that aryl, phenyl, biphenyl, or naphthyl, may optionally be substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl (optionally substituted by hydroxy, carboxy, amino (optionally substituted by one or two linear or branched (C1-C6)alkyl groups) or carbamoyl (optionally substituted by one or two linear or branched (C1-C6)alkyl groups)), linear or branched (C1-C6)alkoxy, hydroxy, linear or branched (C1-C6)trihaloalkyl, linear or branched (C1-C6)trihaloalkoxy, amino (optionally substituted by one or two linear or branched (C1-C6)alkyl groups), linear or branched (C1-C6)alkylcarbonyloxy, carboxymethoxy and carbamoylmethoxy (optionally N-substituted by one or two linear or branched (C1-C6)alkyl groups), heteroaryl being understood to be an aromatic mono- or bi-cyclic group having from 5 to 12 ring members containing one, two or three hetero atoms selected from oxygen, nitrogen and sulphur, wherein the heteroaryl may be optionally substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl (optionally substituted by hydroxy, carboxy, amino (optionally substituted by one or two linear or branched (C1-C6)alkyl groups) or carbamoyl (optionally substituted by one or two linear or branched (C1-C6)alkyl groups)), hydroxy, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)trihaloalkyl, phenyl, amino (optionally N-substituted by one or more linear or branched (C1-C6)alkyl groups), carboxymethoxy and carbamoylmethoxy (optionally substituted by one or two linear or branched (C1-C6)alkyl groups), cycloalkyl being understood to be a saturated or unsaturated, mono- or bi-cyclic hydrocarbon group having from 3 to 12 ring members, wherein the ring may optionally be substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, hydroxy, linear or branched (C1-C6)trihaloalkyl, amino (optionally substituted by one or more linear or branched (C1-C6)alkyl groups) and aryl, a heterocycloalkyl group being understood to be a saturated or unsaturated, mono- or bi-cyclic group having from 4 to 12 ring members containing one, two or three hetero atoms selected from oxygen, nitrogen and sulphur, wherein the heterocycle may optionally be substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, hydroxy, linear or branched (C1-C6)trihaloalkyl, amino (optionally substituted by one or more linear or branched (C1-C6)alkyl groups), aryl and diarylmethyl.