FKBP inhibitors

A compound of the formula (I):

• or a pharmaceutically acceptable salt or solvate or stereoisomer thereof, wherein:
• X is NH or N(C1-6alkyl);
• R1, R2, R3 and R4 are each independently H, OH, OCO (C1-6alkyl), CO2(C1-6alkyl), CONH2CONH(C1-6alkyl), CON(C1-6alkyl)2, halo, C3-7 cycloalkyl, C3-7 cycloalkyloxy, C2-6 alkenyl, aryl1, C1-6 alkyl optionally substituted by one or more substituents selected from halo and C3-7 cycloalkyl, and C1-6alkoxy optionally substituted by one or more substituents selected from fluoro and C3-7 cycloalkyl;
• A is unbranched butylene optionally substituted by up to three C1-6 alkyl groups;
• D is O or S;
• E is NH or N(C1-6alkyl);
• G is C1-14 alkyl or C2-14 alkenyl, each of which is optionally substituted by one or more substituents independently selected from halo, aryl, C1-4 alkoxy, cycloalk, het and NR5R6,
• R5 and R6 are either each independently H or C1-6 alkyl, or are taken together to form, with the nitrogen atom to which they are attached, a 4 to 7-membered heterocyclic ring optionally containing another hetero-moiety selected from NR7, O and S(O)p, and which 4 to 7-membered heterocyclic ring is optionally substituted by up to 3 substituents independently selected from C1-6 alkyl and C1-6 alkoxy;
• R7 is H, C1-5 alkyl, C2-6 alkenyl, COR8, SO2R8, CONR9R10, CO2R8 or SO2NR9R10;
• R8 is C3-7 cycloalkyl, C2-6 alkenyl, aryl1, or C1-6 alkyl optionally substituted by C3-7 cycloalkyl or aryl1;
• R9 and R10 are each independently H, C2-6 alkenyl, C3-7 cycloalkyl, or C1-6 alkyl optionally substituted by C3-7 cycloalkyl or aryl;
• p is 0, 1 or 2;
• wherein “aryl” means phenyl or naphthyl, each of which is optionally substituted by up to 3 substitutents independently selected from C1-6 alkyl optionally substituted by one or more halo or C3-7cycloalkyl groups, C2-6 alkenyl, C1-6 alkoxy, C2-6 alkenyloxy, OH, halo, NO2, phenyloxy, benzyloxy, phenyl and NH2;
• “aryl1” means phenyl, naphthyl or benzyl, each of which is optionally substituted by 1 or 2 substituents independently selected from C1-6 alkyl optionally substituted by one or more halo or C3-7 cycloalkyl groups, C1-6 alkoxy and halo;
• “cycloalk” is C3-8 cycloalkyl optionally substituted by up to 3 substutents independently selected from C2-6 alkenyl, C1-6 alkoxy, C2-6 alkenyloxy, OH, halo, and C1-6 alkyl optionally substituted by one or more halo;
• and “het” means a 5- or 6-membered monocyclic, or 8-, 9- or 10-membered bicyclic heterocycle containing 1 to 3 heteroatoms independently selected from O, N and S, which is optionally substituted by one or more halo or C3-7 cycloalkyl groups, C2-6 alkenyl, C 1-6 alkoxy, C2-6 alkenyl, OH, halo, NO2, phenyloxy, benzyloxy and NH2.