Back to results
US 6,686,352 B2Granted
Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
AssigneeHoffmann-La Roche Inc.
InventorsRaffaello Masciadri, Andrew William Thomas, Juergen Wichmann
Life of this patent
Estimating the term…
Abstract
The present invention is a compound of formula wherein R1 is halogen or lower alkyl; R2 is hydrogen, lower alkyl, cycloalkyl, —(CH2)m-phenyl, wherein the phenyl ring may be substituted by lower alkoxy, or is —(CH2)m-indolyl; R3 is —C(O)O-lower alkyl, —C(O)OH, or a five membered heteroaromatic group, which rings may be substituted by lower alkyl or cycloalkyl; n is 0, 1 or 2; m is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof. Compound I shows high affinity and selectivity for GALA A α5 receptor binding sites.
Claims12
A compound of formula:
- wherein
- R1 is selected from the group consisting of halogen and lower alkyl;
- R2 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, —(CH2)m-phenyl, —(CH2)m-phenyl substituted by lower alkoxy and —(CH2)m-indolyl;
- R3 is selected from the group consisting of —(O)O-lower alkyl, —C(O)OH, an unsubstituted five-membered heteroaromatic group and a five-membered heteroaromatic group substituted by lower alkyl or cycloalkyl;
- n is 0, 1 or 2;and
- m is 0, 1 or 2;
- or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.