Collection device
AssigneeBecton, Dickinson and Company
InventorsNancy E. Dubrowny, Andrew J. Harrop
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Abstract
The present invention is a container assembly that includes a coating composition on an interior surface of the container assembly and more particularly a coating composition for rapid clotting of a blood sample within a blood collection tube. The coating composition includes an intrinsic coagulation activator and an extrinsic coagulation activator for activating intrinsic and extrinsic pathways for promoting the rapid clotting of the blood sample. In addition, the present invention includes a barrier package for enclosing the container assembly.
Claims31
A method of promoting clotting of a blood sample in a blood collection receptacle by activating intrinsic and extrinsic blood clotting pathways of the sample comprising the steps of:
- applying a coating of an intrinsic coagulation activator to an interior surface of said receptacle or to a base coating disposed on the interior surface of said receptacle;
- and
- applying a coating of an extrinsic coagulation activator over said coating of said intrinsic coagulation activator.
A method of promoting clotting of a blood sample in a blood collection receptacle by activating intrinsic and extrinsic blood clotting pathways of the sample comprising the steps of:
- applying polyvinylpyrrolidone and a water soluble silicone surfactant to an interior surface of said receptacle;
- drying said polyvinylpyrrolidone and said water soluble silicone surfactant to form a first coating layer;
- applying an intrinsic coagulation activator over said first coating layer;
- drying said intrinsic coagulation activator to form a second coating layer;
- applying an extrinsic coagulation activator over said second coating layer;
- and
- drying said extrinsic coagulation activator to form a third coating layer.
An assembly comprising:
- a receptacle having a water vapor permeability of less than about 1.0 g/m2/day;
- and
- an evacuated blood collection tube contained within said receptacle, said tube having a coating on an interior surface for promoting clotting of a blood sample by activating intrinsic and extrinsic pathways of the sample, said coating comprising an intrinsic coagulation activator in conjunction with an extrinsic coagulation activator.
A blood collection tube having an interior surface with a coating, said coating comprising:
- a first coating layer comprising an intrinsic coagulation activator applied to said interior surface or applied to a base coating disposed over said interior surface;
- and
- a second coating layer comprising an extrinsic coagulation activator applied to said first coating layer.
Dependencies are inferred from the claim text.