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US 6,686,188 B2Granted
Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
AssigneeAmersham PLC
InventorsYizhong Gu, Yonggang Ji, Sharron Gaynor Penn, David Kagen Hanzel, David Russell Rank, Wensheng Chen, Mark E. Shannon
Life of this patent
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Abstract
Presented are a novel myosin-like protein particularly expressed in human heart and muscle, isolated nucleic acids encoding the myosin-like protein, compounds and compositions derivable directly or indirectly therefrom, and diagnostic and therapeutic methods for using the same.
Claims50
An isolated nucleic acid comprising:
- a polynucleotide having a sequence selected from the group consisting of (i) the nucleotide sequence of SEQ ID NO:1, (ii) the nucleotide sequence of SEQ ID NO:2, (iii) a nucleotide sequence that is a degenerate variant of the nucleotide sequence of SEQ ID NO:2, (iv) a nucleotide sequence at least 90% identical in sequence to SEQ ID NO:2, (v) a nucleotide sequence that encodes a polypeptide with the amino acid sequence of SEQ ID NO:3, (vi) a nucleotide sequence that encodes a polypeptide at least 90% identical in sequence to SEQ ID NO:3, and (vii) a nucleotide sequence that is the complete complement of the nucleotide sequence of any one of (i)-(vi), wherein said nucleic acid encodes a polypeptide having ATPase activity or a polypeptide capable of binding calmodulin.
An isolated nucleic acid comprising:
- a polynucleotide having a sequence selected from the group consisting of (i) the nucleotide sequence of SEQ ID NO:1, (ii) the nucleotide sequence of SEQ ID NO:2, (iii) a nucleotide sequence that is a degenerate variant of the nucleotide sequence of SEQ ID NO:2, (iv) a nucleotide sequence at least 95% identical in sequence to SEQ ID NO:2, (v) a nucleotide sequence that encodes a polypeptide with the amino acid sequence of SEQ ID NO:3, (vi) a nucleotide sequence that encodes a polypeptide at least 95% identical in sequence to SEQ ID NO:3, and (vii) a nucleotide sequence that is the complete complement of the nucleotide sequence of any one of (i)-(vi), wherein said nucleic acid encodes a polypeptide having ATPase activity or a polypeptide capable of binding calmodulin.
An isolated nucleic acid comprising:
- a polynucleotide having a sequence selected from the group consisting of (i) the nucleotide sequence of SEQ ID NO:1, (ii) the nucleotide sequence of SEQ ID NO:2, (iii) a nucleotide sequence that is a degenerate variant of the nucleotide sequence of SEQ ID NO:2, (iv) a nucleotide sequence at least 99% identical in sequence to SEQ ID NO:2, (v) a nucleotide sequence that encodes a polypeptide with the amino acid sequence of SEQ ID NO:3, (vi) a nucleotide sequence that encodes a polypeptide at least 99% identical in sequence to SEQ ID NO:3, and (vii) a nucleotide sequence that is the complete complement of the nucleotide sequence of any one of (i)-(vi), wherein said nucleic acid encodes a polypeptide having ATPase activity or a polypeptide capable of binding calmodulin.
Dependencies are inferred from the claim text.